A study of the association between polymorphisms in the genes for interleukins IL-6 and IL-10 and negative symptoms subdomains in schizophrenia.

ABSTRACT:

Background

Schizophrenia is a severe mental illness manifested by various symptoms. Negative symptoms (NS) are associated with disability and poor function of patients. The study of NS neurobiology is complicated by their heterogeneity. Factor analysis revealed two distinct NS subdomains with different pathophysiological mechanisms: volitional pathology, including avolition and apathy (AA), and diminished expression (DE). Inflammation is one mechanism that may underlie NS, including their heterogeneity.

Aims

To search for the association between genes for interleukins (IL-6 -174 G/C, IL-10 -592 C/A, and IL-10 -1082 G/A) and NS subdomains.

Materials and methods

The study included 275 patients with schizophrenia. NS factors were calculated based on

SUBMITTER: Golimbet V 

PROVIDER: S-EPMC9707661 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature