Effects of an exogenous ketone ester using multi-omics in skeletal muscle of aging C57BL/6J male mice.

ABSTRACT: Exogenous ketone ester supplementation provides a means to increase circulating ketone concentrations without the dietary challenges imposed by ketogenic diets. Our group has shown that oral R,S-1,3, butanediol diacetoacetate (BD-AcAc₂) consumption results in body weight loss or maintenance with moderate increases in circulating ketones. We have previously shown a diet consisting of 25% BD-AcAc₂ can maintain lean body mass (LBM) and induce fat mass (FM) loss in young, healthy male mice, but the underlying mechanisms are still unknown. Therefore, the purpose of this study was to determine if a diet consisting of 25% BD-AcAc₂ (ketone ester, KE) would alter body composition, transcriptional regulation, the proteome, and the lipidome of skeletal muscle in aged

SUBMITTER: Roberts BM 

PROVIDER: S-EPMC9707703 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature