Differential immune transcriptomic profiles between vaccinated and resolved HCV reinfected subjects.

ABSTRACT: Successive episodes of hepatitis C virus (HCV) infection represent a unique natural rechallenge experiment to define correlates of long-term protective immunity and inform vaccine development. We applied a systems immunology approach to characterize longitudinal changes in the peripheral blood transcriptomic signatures in eight subjects who spontaneously resolved two successive HCV infections. Furthermore, we compared these signatures with those induced by an HCV T cell-based vaccine regimen. We identified a plasma cell transcriptomic signature during early acute HCV reinfection. This signature was absent in primary infection and following HCV vaccine boost. Spontaneous resolution of HCV reinfection was associated with rapid expansion of glycoprotein E2-specifc memory B cells in three subj

SUBMITTER: Mazouz S 

PROVIDER: S-EPMC9707775 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature