Comparative analysis reveals the long-term coevolutionary history of parvoviruses and vertebrates.

ABSTRACT: Parvoviruses (family Parvoviridae) are small DNA viruses that cause numerous diseases of medical, veterinary, and agricultural significance and have important applications in gene and anticancer therapy. DNA sequences derived from ancient parvoviruses are common in animal genomes and analysis of these endogenous parvoviral elements (EPVs) has demonstrated that the family, which includes twelve vertebrate-specific genera, arose in the distant evolutionary past. So far, however, such "paleovirological" analysis has only provided glimpses into the biology of ancient parvoviruses and their long-term evolutionary interactions with hosts. Here, we comprehensively map EPV diversity in 752 published vertebrate genomes, revealing defining aspects of ecology and evolution within individual parvoviru

SUBMITTER: Campbell MA 

PROVIDER: S-EPMC9707805 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature