The Use and Duration of Preintubation Respiratory Support Is Associated With Increased Mortality in Immunocompromised Children With Acute Respiratory Failure.

ABSTRACT:

Objectives

To determine the association between preintubation respiratory support and outcomes in patients with acute respiratory failure and to determine the impact of immunocompromised (IC) diagnoses on outcomes after adjustment for illness severity.

Design

Retrospective multicenter cohort study.

Setting

Eighty-two centers in the Virtual Pediatric Systems database.

Patients

Children 1 month to 17 years old intubated in the PICU who received invasive mechanical ventilation (IMV) for greater than or equal to 24 hours.

Interventions

None.

Measurements and main results

High-flow nasal cannula (HFNC) or noninvasive positive-pressure ventilation (NIPPV) or both were used prior to intubation in 1,825 (34%) of 5,348 PICU intubations across 82 centers. W

SUBMITTER: Lindell RB 

PROVIDER: S-EPMC9707852 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature