Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy.

ABSTRACT:

Background

Defects in energetics are thought to be central to the pathophysiology of hypertrophic cardiomyopathy (HCM); yet, the determinants of ATP availability are not known. The purpose of this study is to ascertain the nature and extent of metabolic reprogramming in human HCM, and its potential impact on contractile function.

Methods

We conducted proteomic and targeted, quantitative metabolomic analyses on heart tissue from patients with HCM and from nonfailing control human hearts.

Results

In the proteomic analysis, the greatest differences observed in HCM samples compared with controls were increased abundances of extracellular matrix and intermediate filament proteins and decreased abundances of muscle creatine kinase and mitochondrial proteins involved in fatt

SUBMITTER: Previs MJ 

PROVIDER: S-EPMC9708114 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature