A systematic literature review to evaluate extended dosing intervals in the pharmacological management of acromegaly.

ABSTRACT:

Purpose

This systematic literature review investigated whether extended dosing intervals (EDIs) of pharmacological acromegaly treatments reduce patient burden and costs compared with standard dosing, while maintaining effectiveness.

Methods

MEDLINE/Embase/the Cochrane Library (2001-June 2021) and key congresses (2018-2021) were searched and identified systematic literature review bibliographies reviewed. Included publications reported on efficacy/effectiveness, safety and tolerability, health-related quality of life (HRQoL), and patient-reported and economic outcomes in longitudinal/cross-sectional studies in adults with acromegaly. Interventions included EDIs of pegvisomant, cabergoline, and somatostatin receptor ligands (SRLs): lanreotide autogel/depot (LAN), octreotide lo

SUBMITTER: Fleseriu M 

PROVIDER: S-EPMC9708130 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature