Heme oxygenase-1 as a predictor of sepsis-induced acute kidney injury: a cross-sectional study

ABSTRACT:

Background

Sepsis patients suffer from severe inflammation and poor prognosis. Oxidative stress and local inflammation that results from sepsis can trigger organ injury, including acute kidney injury (AKI). Previous studies have shown that heme oxygenase-1 (HO-1) is overexpressed in proximal tubular cells under oxidative stress and has significant cytoprotective and anti-inflammatory effects. Heme-induced inflammation in sepsis is antagonized by increased tissue expression of heme oxygenase-1 (HO-1), which impacts on AKI development. The investigators observed intrarenal HO-1 expression and corresponding potential increases in plasma and urinary HO-1 protein concentrations in four different AKI models. Since serum levels of HO-1 reflect HO-1 expression, we aimed to investigate whe

SUBMITTER: Xia S 

PROVIDER: S-EPMC9708490 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature