Mending a broken heart—targeting cardiomyocyte regeneration: a literature review

ABSTRACT:

Background and Objectives

Cardiovascular diseases have been the leading cause of death globally for decades. Pharmacological advances targeting the sympathetic nervous system, renin-angiotensin-aldosterone system, and fibrosis slow the progression of diverse cardiovascular diseases. However, ongoing cardiomyocyte loss is inevitable in divergent cardiovascular diseases, eventually leading to heart failure as the end stage. In this review, we focused on the key biomedical findings and underlying principles of cardiomyocyte regeneration.

Methods

Literature regarding the key findings in cardiomyocyte regeneration research, including controversies on the origins of newly formed cardiomyocytes, potential barriers and strategies to heart regeneration, and the key animals, models

SUBMITTER:  

PROVIDER: S-EPMC9708497 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature