The relationship between glutamate, dopamine, and cortical gray matter: A simultaneous PET-MR study.

ABSTRACT: Prefrontal cortex has been shown to regulate striatal dopaminergic function via glutamatergic mechanisms in preclinical studies. Concurrent disruption of these systems is also often seen in neuropsychiatric disease. The simultaneous measurement of striatal dopamine signaling, cortical gray matter, and glutamate levels is therefore of major interest, but has not been previously reported. In the current study, twenty-eight healthy subjects underwent 2 simultaneous [¹¹C]-( + )-PHNO PET-MRI scans, once after placebo and once after amphetamine in a double-blind randomized cross-over design, to measure striatal dopamine release, striatal dopamine receptor (D_2/3R) availability, anterior cingulate glutamate+glutamine (Glx) levels, and cortical gray matter volumes at the same

SUBMITTER: Rogeau A 

PROVIDER: S-EPMC9708555 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature