Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses-a general population study.

ABSTRACT: A strong genetic background for psychoses is well-established. Most individuals with a high genetic risk for schizophrenia, however, do not develop the disorder. We investigated whether individuals, who have a high genetic risk for schizophrenia but no non-affective psychotic disorders, are predisposed to develop milder forms of deviant thinking in terms of magical thinking. Participants came from the population-based Young Finns Study (n = 1292). The polygenic risk score for schizophrenia (PRS) was calculated on the basis of the most recent genome-wide association study (GWAS). Psychiatric diagnoses over the lifespan were collected up to 2017 from the registry of hospital care. Magical thinking was evaluated with the Spiritual Acceptance Scale (e.g., beliefs in telepathy, miracles, mystic

SUBMITTER: Saarinen A 

PROVIDER: S-EPMC9708578 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature