Neuroinflammation in HIV-associated depression: evidence and future perspectives.

ABSTRACT: People living with HIV face a high risk of mental illness, especially depression. We do not yet know the precise neurobiological mechanisms underlying HIV-associated depression. Depression severity in the general population has been linked to acute and chronic markers of systemic inflammation. Given the associations between depression and peripheral inflammation, and since HIV infection in the brain elicits a neuroinflammatory response, it is possible that neuroinflammation contributes to the high prevalence of depression amongst people living with HIV. The purpose of this review was to synthesise existing evidence for associations between inflammation, depression, and HIV. While there is strong evidence for independent associations between these three conditions, few preclinical or clinic

SUBMITTER: Mudra Rakshasa-Loots A 

PROVIDER: S-EPMC9708589 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature