Rest-activity rhythms and tract specific white matter lesions in older adults at risk for cognitive decline.

ABSTRACT: White matter lesions (WMLs) are common in older adults and represent an important predictor of negative long-term outcomes. Rest-activity rhythm disturbance is also common, however, few studies have investigated associations between these factors. We employed a novel AI-based automatic WML segmentation tool and diffusion-weighted tractography to investigate associations between tract specific WML volumes and non-parametric actigraphy measures in older adults at risk for cognitive decline. The primary non-parametric measures of interest were inter-daily stability (IS), intra-daily variability and relative amplitude, with the anterior thalamic radiation (ATR), superior longitudinal fasciculus (SLF) and inferior longitudinal fasciculus (ILF) selected as tracts of interest. One hundred and eig

SUBMITTER: Palmer JR 

PROVIDER: S-EPMC9708592 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature