Proteins associated with future suicide attempts in bipolar disorder: A large-scale biomarker discovery study.

ABSTRACT: Suicide is a major cause of death worldwide. Several biological systems have been implicated in suicidal behavior but studies of candidate biomarkers have failed to produce clinically relevant biomarkers for suicide prediction. The objective of the present study was to identify novel candidate biomarkers for suicidal behavior. We used a nested case-control study design where a large cohort of patients with bipolar disorder (N = 5 110) were followed up to 8 years after blood sampling. We included patients that attempted suicide during follow-up (N = 348) and matched bipolar disorder patients from the same cohort who did not attempt suicide during the study period (N = 348) and analyzed a total of 92 proteins with a neuro exploratory multiplex panel. Using a multivariate classification algor

SUBMITTER: Sandberg JV 

PROVIDER: S-EPMC9708594 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature