Cerebrospinal fluid biomarkers in SARS-CoV-2 patients with acute neurological syndromes.

ABSTRACT:

Background and purpose

Mechanisms underlying acute brain injury in SARS-CoV-2 patients remain poorly understood. A better characterization of such mechanisms remains essential to preventing long-term neurological sequelae. Our present aim was to study a panel of biomarkers of neuroinflammation and neurodegeneration in the cerebrospinal fluid (CSF) of NeuroCOVID patients.

Methods

We retrospectively collected clinical and CSF biomarkers data from 24 NeuroCOVID adults seen at the University Hospital of Guadeloupe between March and June 2021.

Results

Among 24 NeuroCOVID patients, 71% had encephalopathy and 29% meningoencephalitis. A number of these patients also experienced de novo movement disorder (33%) or stroke (21%). The CSF analysis revealed intrathecal immunoglobul

SUBMITTER: Chaumont H 

PROVIDER: S-EPMC9708608 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature