The APOE locus is linked to decline in general cognitive function: 20-years follow-up in the Doetinchem Cohort Study.

ABSTRACT: Cognitive decline is part of the normal aging process. However, some people experience a more rapid decline than others due to environmental and genetic factors. Numerous single nucleotide polymorphisms (SNPs) have been linked to cognitive function, but only a few to cognitive decline. To understand whether cognitive function and cognitive decline are driven by the same mechanisms, we investigated whether 433 SNPs previously linked to cognitive function and 2 SNPs previously linked to cognitive decline are associated with both general cognitive functioning at baseline and general cognitive decline up to 20-years follow-up in the Doetinchem Cohort Study (DCS). The DCS is a longitudinal population-based study that enrolled men and women aged 20-59 years between 1987-1991, with follow-up exam

SUBMITTER: Rietman ML 

PROVIDER: S-EPMC9708640 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature