Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies.

ABSTRACT: Effortful control comprises attentional control, inhibitory control, and cognitive flexibility subprocesses. Effortful control is impaired in individuals with autism spectrum disorder, yet its neural underpinnings remain elusive. By conducting a coordinate-based meta-analysis, this study compared the brain activation patterns between autism and typically developing individuals and examined the effect of age on brain activation in each effortful control subprocesses. Meta-analytic results from 22 studies revealed that, individuals with autism showed hypoactivation in the default mode network for tasks tapping inhibitory control functioning (threshold-free cluster enhancement p < 0.001). When these individuals perform tasks tapping attentional control and cognitive flexibility, they exhibite

SUBMITTER: Krishnamurthy K 

PROVIDER: S-EPMC9708641 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature