The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry.

ABSTRACT: Psoriasis is a common chronic inflammatory skin disease. The diversity and heterogeneity of immune cells in human skin have been studied in recent years, but the spatial distribution of immune cells at the single-cell level in the human psoriatic epidermis and dermis remains unclear. In this study, we mapped psoriatic skin immune cells from paired lesional, perilesional, and nonlesional skin samples using mass cytometry. Phenotypic dendritic cells (DCs) were found in the psoriatic epidermis and dermis. Psoriatic dermal CD1c⁺CD11b⁺ cDC2s migrated to the epidermis in the perilesional skin during the preinitiation stage. CD1c⁺CD11b⁺ cDC2s rapidly replaced EpCAM⁺CD11c^low LC cells and initiated inflammation. Simultaneously, CD207

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC9708662 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature