Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects.

ABSTRACT: Deep skin wounds with periosteal defects, frequently caused by traffic accidents or radical dissection, are refractory. Transplant surgery is frequently performed, but patients are subjected to stress for long operation periods, the sacrifice of donor regions, or several complications, such as flap necrosis or intractable ulcers. Even if the defects are covered, a scar composed of fibrous tissue remains in the body, which can cause itching, dysesthesia, or repeated ulcers because of the lack of distribution of peripheral nerves or hair follicles. Thus, treatments with the aim of regenerating lost tissue for deep wounds with periosteal defects are needed. Here, we show that the use of gelatin sponges (GS), which have been used as haemostatic materials in clinical practice, allowed the regen

SUBMITTER: Shirai Y 

PROVIDER: S-EPMC9708684 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature