Closed-loop oxygen control improves oxygenation in pediatric patients under high-flow nasal oxygen-A randomized crossover study.

ABSTRACT:

Background

We assessed the effect of a closed-loop oxygen control system in pediatric patients receiving high-flow nasal oxygen therapy (HFNO).

Methods

A multicentre, single-blinded, randomized, and cross-over study. Patients aged between 1 month and 18 years of age receiving HFNO for acute hypoxemic respiratory failure (AHRF) were randomly assigned to start with a 2-h period of closed-loop oxygen control or a 2-h period of manual oxygen titrations, after which the patient switched to the alternative therapy. The endpoints were the percentage of time spent in predefined SpO₂ ranges (primary), FiO₂, SpO₂/FiO₂, and the number of manual adjustments.

Findings

We included 23 patients, aged a median of 18 (3-26) months. Patients s

SUBMITTER: Sandal O 

PROVIDER: S-EPMC9708705 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature