Elevated ubiquitination contributes to protective immunity against severe SARS-CoV-2 infection.

ABSTRACT:

Background

The crosstalk between the ubiquitin-proteasome and the immune system plays an important role in the health and pathogenesis of viral infection. However, there have been few studies of ubiquitin activation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Methods

We investigated the effect of ubiquitination on SARS-CoV-2 infection and patient prognosis by integrating published coronavirus disease 2019 (COVID-19) multi-transcriptome data and bioinformatics methods.

Results

The differential expression of COVID-19 samples revealed changed ubiquitination in most solid and hollow organs, and it was activated in lymphatic and other immune tissues. In addition, in the respiratory system of COVID-19 patients, the immune response was mainly f

SUBMITTER: Che Y 

PROVIDER: S-EPMC9708907 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature