Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease.

ABSTRACT:

Background

Celiac disease (CeD) is often accompanied by other autoimmune diseases (AID). However, the association of co-existing autoimmunity with the presentation and treatment success in CeD is unclear. We investigated these issues with a large and well-defined cohort of Finnish patients.

Methods

Adult CeD patients (n = 806) were collected from multiple heath care sites via nationwide recruitment. They were interviewed, underwent measurement of CeD autoantibodies, and filled out questionnaires to ascertain quality of life (PGWB) and gastrointestinal symptoms (GSRS) after a median of 9.7 years on a gluten-free diet. Data were supplemented retrospectively from patient records. The results were compared between CeD patients with and without a coexisting AID.

SUBMITTER: Tauschi R 

PROVIDER: S-EPMC9709120 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature