Comparative genomics reveals new insights into the evolution of the IncA and IncC family of plasmids.

ABSTRACT: Incompatibility groups IncA and IncC plasmids are of great concern due to their ability to disseminate antibiotic resistance in bacteria via conjugative transfer. A deep understanding of their genomic structures and evolutionary characteristics is of great significance for improving our knowledge about its multidrug-resistance evolution and dissemination. However, current knowledge of their backbone structure, features of core functional modules and the characteristics of variable regions is based on a few plasmids, which highlights the need for a comprehensive systematic study. The present study thoroughly compared and analysed 678 IncA and IncC plasmid genomes. We found that their core functional genes were occasionally deficient and sometimes existed as multiple functional copies/multip

SUBMITTER: Zhang F 

PROVIDER: S-EPMC9709138 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature