Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice.
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ABSTRACT:
SUBMITTER: Rodrigues D
PROVIDER: S-EPMC9709160 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice.
Rodrigues Diana D Jacinto Luis L Falcão Margarida M Castro Ana Carolina AC Cruz Alexandra A Santa Cátia C Manadas Bruno B Marques Fernanda F Sousa Nuno N Monteiro Patricia P
Nature communications 20221129 1
Chronic stress (CS) is associated with a number of neuropsychiatric disorders, and it may also contribute to or exacerbate motor function. However, the mechanisms by which stress triggers motor symptoms are not fully understood. Here, we report that CS functionally alters dorsomedial striatum (DMS) circuits in male mice, by affecting GABAergic interneuron populations and somatostatin positive (SOM) interneurons in particular. Specifically, we show that CS impairs communication between SOM intern ...[more]
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