Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development.

ABSTRACT: The use of antibiotics leads to antibiotic residues in livestock and poultry products, adversely affecting human health. Ciprofloxacin (CFX) is a broad-spectrum antibiotic shared between animals and humans that is useful in treatments besides infections. However, changes in the gut microbiota caused by CFX and the possible link with the elimination of CFX residues have not been investigated. Herein, we used the Silkie chicken model to study the changes in the gut microbiota during the entire CFX-metabolic repertoire. We detected CFX residues in different tissues and showed that the elimination time of CFX from different tissues was dissimilar (liver > kidney > chest muscle > skin). Analysis of liver and kidney injury biomarkers and plasma antioxidant indices indicated slight hepatotoxicity

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC9709234 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature