PLTP is a p53 target gene with roles in cancer growth suppression and ferroptosis.

ABSTRACT: The tumor suppressor protein p53 suppresses cancer by regulating processes such as apoptosis, cell cycle arrest, senescence, and ferroptosis, which is an iron-mediated and lipid peroxide-induced cell death pathway. Whereas numerous p53 target genes have been identified, only a few appear to be critical for the suppression of tumor growth. Additionally, while ferroptosis is clearly implicated in tumor suppression by p53, few p53 target genes with roles in ferroptosis have been identified. We have previously studied germline missense p53 variants that are hypomorphic or display reduced activity. These hypomorphic variants are associated with increased risk for cancer, but they retain the majority of p53 transcriptional function; as such, study of the transcriptional targets of these hypomorp

SUBMITTER: Gnanapradeepan K 

PROVIDER: S-EPMC9709240 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature