The mixed spongiotic and interface reaction pattern: A study of clinical and histopathologic findings.

ABSTRACT:

Background

Categorization of biopsy specimens into inflammatory reaction patterns is central to dermatopathologic assessment. Mixed inflammatory patterns are poorly characterized and may represent clinicopathologic challenges. The purpose of this study was to identify clinical and histopathologic findings associated with the mixed spongiotic-interface dermatitis (SID) histopathologic pattern.

Methods

Fifty-one institutional biopsy specimens of SID were identified over a 2-year period by retrospective natural language search. Histopathologic and clinical features were identified.

Results

The most common histopathologic features associated with SID were mild spongiosis (51%), focal vacuolar interface change (72%), lymphocytic exocytosis (92%), and superficial-dermal lym

SUBMITTER: Ernst M 

PROVIDER: S-EPMC9709294 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature