A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization.

ABSTRACT: Decidualization is the hormone-dependent process of endometrial remodeling that is essential for fertility and reproductive health. It is characterized by dynamic changes in the endometrial stromal compartment including differentiation of fibroblasts, immune cell trafficking and vascular remodeling. Deficits in decidualization are implicated in disorders of pregnancy such as implantation failure, intra-uterine growth restriction, and pre-eclampsia. Androgens are key regulators of decidualization that promote optimal differentiation of stromal fibroblasts and activation of downstream signaling pathways required for endometrial remodeling. We have shown that androgen biosynthesis, via 5α-reductase-dependent production of dihydrotestosterone, is required for optimal decidualization of

SUBMITTER: Shaw IW 

PROVIDER: S-EPMC9709457 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature