Protective interaction of human phagocytic APC subsets with <i>Cryptococcus neoformans</i> induces genes associated with metabolism and antigen presentation.

ABSTRACT: Cryptococcal meningitis is the most common cause of meningitis among HIV/AIDS patients in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than 181,000 annual deaths. Usually, the fungus gets inhaled into the lungs where the initial interactions occur with pulmonary phagocytes such as dendritic cells and macrophages. Following phagocytosis, the pathogen can be killed or can replicate intracellularly. Previous studies in mice showed that different subsets of these innate immune cells can either be antifungal or permissive for intracellular fungal growth. Our studies tested phagocytic antigen-presenting cell (APC) subsets from the human lung against C. neoformans. Human bronchoalveolar lavage was processed for phagocytic APCs and incubated with C. neoform

SUBMITTER: Nelson BN 

PROVIDER: S-EPMC9709479 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature