A convenient catalytic method for preparation of new tetrahydropyrido[2,3-d]pyrimidines via a cooperative vinylogous anomeric based oxidation.

ABSTRACT: In this study, a novel functionalized metal-organic frameworks MIL-125(Ti)-N(CH₂PO₃H₂)₂ was designed and synthesized via post-modification methodology. Then, MIL-125(Ti)-N(CH₂PO₃H₂)₂ as a mesoporous catalyst was applied for the synthesis of a wide range of novel tetrahydropyrido[2,3-d]pyrimidines as bioactive candidate compounds by one-pot condensation reaction of 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile, 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione and aromatic aldehydes at 100 °C under solvent-free condition. Interestingly, the preparation of tetrahydropyrido[2,3-d]pyrimidine was achieved via vinylogous anomeric based oxidation mechanism with

SUBMITTER: Sepehrmansourie H 

PROVIDER: S-EPMC9709663 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature