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Subgenomic RNA Abundance Relative to Total Viral RNA Among Severe Acute Respiratory Syndrome Coronavirus 2 Variants.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subgenomic RNA (sgRNA) may indicate actively replicating virus, but sgRNA abundance has not been systematically compared between SARS-CoV-2 variants. sgRNA was quantified in 169 clinical samples by real-time reverse-transcription polymerase chain reaction, demonstrating similar relative abundance among known variants. Thus, sgRNA detection can identify individuals with active viral replication regardless of variant.

SUBMITTER: Su M 

PROVIDER: S-EPMC9709700 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Subgenomic RNA Abundance Relative to Total Viral RNA Among Severe Acute Respiratory Syndrome Coronavirus 2 Variants.

Su Maxwell M   Ping Sara S   Nguyen Phuong-Vi PV   Rojas Alejandra A   Hussaini Laila L   Carmola Ludy Registre LR   Taz Azmain A   Sullivan Julie J   Martin Greg S GS   Piantadosi Anne A   Martinez Magaly M   Lam Wilbur A WA   Anderson Evan J EJ   Waggoner Jesse J JJ  

Open forum infectious diseases 20221110 11

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subgenomic RNA (sgRNA) may indicate actively replicating virus, but sgRNA abundance has not been systematically compared between SARS-CoV-2 variants. sgRNA was quantified in 169 clinical samples by real-time reverse-transcription polymerase chain reaction, demonstrating similar relative abundance among known variants. Thus, sgRNA detection can identify individuals with active viral replication regardless of variant. ...[more]

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