Essential oils block cellular entry of SARS-CoV-2 delta variant.

ABSTRACT: Aiming to fill a gap in the literature, we aimed to identify the most promising EOs blocking in vitro cellular entry of SARS-CoV-2 delta variant without conferring human cytotoxicity and provide insights into the influence of their composition on these activities. Twelve EOs were characterized by gas chromatography coupled to mass spectrometry. The antiviral and cytotoxicity activities were determined using the cell-based pseudoviral entry with SARS-CoV-2 delta pseudovirus and the XTT assay in HeLa cells expressing human angiotensin-converting enzyme 2 (HeLa ACE-2), respectively. Syzygium aromaticum, Cymbopogon citratus, Citrus limon, Pelargonium graveolens, Origanum vulgare, "Illicium verum", and Matricaria recutita showed EC₅₀ lowered or close to 1 µg/mL but also the lowest CC

SUBMITTER: Torres Neto L 

PROVIDER: S-EPMC9709744 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature