Enzyme-instructed morphology transformation of mitochondria-targeting peptide for the selective eradication of osteosarcoma.

ABSTRACT: The treatment of osteosarcoma involves an adjuvant therapy that combines surgery and chemotherapy. However, considering that children are the main victims of osteosarcoma, replacing such a harsh treatment with a soft but powerful method that ensures a complete cure while having no adverse effects is highly desirable. To achieve this aim, we have developed a supramolecular therapeutic strategy based on morphology-transformable mitochondria-targeting peptides for the eradication of osteosarcoma with enhanced selectivity and reduced side effects. A newly designed micelle-forming amphiphilic peptide, l-Mito-FFYp, consisting of a phosphate substrate for the biomarker enzyme of osteosarcoma alkaline phosphatase (ALP), disassembles in response to the ALP enzyme in the cell membrane to generate po

SUBMITTER: Jeena MT 

PROVIDER: S-EPMC9709777 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature