Ontology highlight
ABSTRACT:
SUBMITTER: Lustig G
PROVIDER: S-EPMC9709797 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
medRxiv : the preprint server for health sciences 20221130
The milder clinical manifestations of Omicron infection relative to pre-Omicron SARS CoV-2 raises the possibility that extensive evolution results in reduced pathogenicity. To test this hypothesis, we quantified induction of cell fusion and cell death in SARS CoV-2 evolved from ancestral virus during long-term infection. Both cell fusion and death were reduced in Omicron BA.1 infection relative to ancestral virus. Evolved virus was isolated at different times during a 6-month infection in an imm ...[more]