Obese mammary tumour-bearing mice are highly sensitive to doxorubicin-induced hepatotoxicity.

ABSTRACT:

Background

Breast cancer is a major health burden for women, worldwide. Lifestyle-related risk factors, such as obesity and being overweight, have reached epidemic proportions and contributes to the development of breast cancer. Doxorubicin (DXR) is a chemotherapeutic drug commonly used to treat breast cancer, and although effective, may cause toxicity to other organs. The mechanisms and effects of DXR on hepatic tissue, and the contributing role of obesity, in breast cancer patients are poorly understood. The aim of this study was therefore to investigate the effects of DXR on hepatic tissue in an obese tumour-bearing mouse model.

Methods

A diet-induced obesity (DIO) mouse model was established, where seventy-four three-week-old female C57BL6 mice were divided into two main

SUBMITTER: Sedeman M 

PROVIDER: S-EPMC9710042 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature