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MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions.

ABSTRACT: DNA loop extrusion emerges as a key process establishing genome structure and function. We introduce MoDLE, a computational tool for fast, stochastic modeling of molecular contacts from DNA loop extrusion capable of simulating realistic contact patterns genome wide in a few minutes. MoDLE accurately simulates contact maps in concordance with existing molecular dynamics approaches and with Micro-C data and does so orders of magnitude faster than existing approaches. MoDLE runs efficiently on machines ranging from laptops to high performance computing clusters and opens up for exploratory and predictive modeling of 3D genome structure in a wide range of settings.

SUBMITTER: Rossini R

PROVIDER: S-EPMC9710047 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions.

Rossini Roberto R Kumar Vipin V Mathelier Anthony A Rognes Torbjørn T Paulsen Jonas J

Genome biology 20221130 1

DNA loop extrusion emerges as a key process establishing genome structure and function. We introduce MoDLE, a computational tool for fast, stochastic modeling of molecular contacts from DNA loop extrusion capable of simulating realistic contact patterns genome wide in a few minutes. MoDLE accurately simulates contact maps in concordance with existing molecular dynamics approaches and with Micro-C data and does so orders of magnitude faster than existing approaches. MoDLE runs efficiently on mach ...[more]

PMID: 36451166

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