Bidirectional genetic overlap between bipolar disorder and intelligence.

ABSTRACT:

Background

Bipolar disorder (BD) is a highly heritable psychiatric illness exhibiting substantial correlation with intelligence.

Methods

To investigate the shared genetic signatures between BD and intelligence, we utilized the summary statistics from genome-wide association studies (GWAS) to conduct the bivariate causal mixture model (MiXeR) and conjunctional false discovery rate (conjFDR) analyses. Subsequent expression quantitative trait loci (eQTL) mapping in human brain and enrichment analyses were also performed.

Results

Analysis with MiXeR suggested that approximately 10.3K variants could influence intelligence, among which 7.6K variants were correlated with the risk of BD (Dice: 0.80), and 47% of these variants predicted BD risk and intelligence in consistent a

SUBMITTER: Shang MY 

PROVIDER: S-EPMC9710050 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature