Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder.

ABSTRACT:

Background

The function of the insula has been increasingly mentioned in neurocircuitry models of obsessive-compulsive disorder (OCD) for its role in affective processing and regulating anxiety and its wide interactions with the classic cortico-striato-thalamo-cortical circuit. However, the insular resting-state functional connectivity patterns in OCD remain unclear. Therefore, we aimed to investigate characteristic intrinsic connectivity alterations of the insula in OCD and their associations with clinical features.

Methods

We obtained resting-state functional magnetic resonance imaging data from 85 drug-free OCD patients and 85 age- and sex-matched healthy controls (HCs). We performed a general linear model to compare the whole-brain intrinsic functional connectivity maps

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC9710058 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature