Identified in blood diet-related methylation changes stratify liver biopsies of NAFLD patients according to fibrosis grade.

ABSTRACT: High caloric diet and lack of physical activity are considered main causes of NAFLD, and a change in the diet is still the only effective treatment of this disease. However, molecular mechanism of the effectiveness of diet change in treatment of NAFLD is poorly understood. We aimed to assess the involvement of epigenetic mechanisms of gene expression regulation in treatment of NAFLD. Eighteen participants with medium- to high-grade steatosis were recruited and trained to follow the Mediterranean diet modified to include fibre supplements. At three timepoints (baseline, after 30 and 60 days), we evaluated adherence to the diet and measured a number of physiological parameters such as anthropometry, blood and stool biochemistry, liver steatosis and stiffness. We also collected whole blood sa

SUBMITTER: Sokolowska KE 

PROVIDER: S-EPMC9710135 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature