Use of proton pump inhibitors and macrolide antibiotics and risk of acute kidney injury: a self-controlled case series study

ABSTRACT:

Background

Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal disorders such as peptic ulcer disease and dyspepsia. However, several studies have suggested that PPI use increases the risk of acute kidney injury (AKI). PPIs are often concomitantly used with antibiotics, such as macrolides and penicillins for Helicobacter pylori eradication. Although macrolide antibiotics are considered to have relatively low nephrotoxicity, they are well known to increase the risk of AKI due to drug-drug interactions. In this study, we aimed to investigate the association between PPI use and the development of AKI. We also evaluated the effect of concomitant use of PPIs and macrolide antibiotics on the risk of AKI.

Methods

This self-controlled case series s

SUBMITTER: Ikuta K 

PROVIDER: S-EPMC9710142 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature