A dual tracer [¹¹C]PBR28 and [¹⁸F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia.

ABSTRACT:

Background

Brain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant potential for targeting with new diagnostic approaches and treatments. However, non-invasive evaluation of these alterations remains a challenge.

Methods

Here, we studied the utility of a micro positron emission tomography (microPET) dual tracer ([¹¹C]PBR28 - for microglial activation and [¹⁸F]FDG for energy metabolism) approach to assess brain dysfunction, including neuroinflammation in murine endotoxemia. MicroPET imaging data were subjected to advanced conjunction and individual analyses, followed by post-hoc analysis.

Results

There were significant increases in [¹¹C]PBR28 and [¹⁸

SUBMITTER: Palandira SP 

PROVIDER: S-EPMC9710165 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature