Pretransplant kidney transcriptome captures intrinsic donor organ quality and predicts 24-month outcomes.

ABSTRACT: With the development of novel prognostic tools derived from omics technologies, transplant medicine is entering the era of precision medicine. Currently, there are no established predictive biomarkers for posttransplant kidney function. A total of 270 deceased donor pretransplant kidney biopsies were collected and posttransplant function was prospectively monitored. This study first assessed the utility of pretransplant gene expression profiles in predicting 24-month outcomes in a training set (n = 174). Nearly 600 differentially expressed genes were associated with 24-month graft function. Grafts that progressed to low function at 24 months exhibited upregulated immune responses and downregulated metabolic processes at pretransplantation. Using penalized logistic regression modeling, a 55

SUBMITTER: Archer KJ 

PROVIDER: S-EPMC9710201 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature