Dataset Information

MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet's disease.

ABSTRACT:

Introduction

The current study was designed to analyze whether polymorphisms of miR-146a and miR-155 are related to Behçet's disease (BD) in the Egyptian population.

Material and methods

A total of 96 unrelated BD patients and 100 healthy subjects were genotyped for miR-146a (rs2910164) and miR-155 (rs767649) using real-time polymerase chain reaction.

Results

The results showed significant elevation in the frequency of rs2910164 GG and CC genotypes in BD patients compared with controls (adjusted OR = 22.156, 95% CI: 4.728-103.818; p < 0.001 and adjusted OR = 40.358, 95% CI: 8.928-182.440; p < 0.001, respectively). Also, the rs2910164 G allele conferred a higher risk of developing BD (adjusted OR = 3.665, 95% CI: 2.013-6.671; p < 0.001). MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance (all p < 0.001), while the miR-155 (rs767649) polymorphism was a risk factor in the recessive model only (p = 0.021). GG and CG genotypes of rs2910164 were associated with higher Behcet's disease current activity index (BDCAI) and ocular involvement compared with CC genotype (p = 0.005 and p = 0.004, respectively). Genotype AT of rs767649 was related to higher BDCAI (p = 0.026) compared with TT and AA genotypes.

Conclusions

miR-146a (rs2910164) and miR-155 (rs767649) are likely to play an important role in the Egyptian population in development of BD and also influence disease severity.

SUBMITTER: Shaker OG

PROVIDER: S-EPMC9710268 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet's disease.

Shaker Olfat G OG Abdelaleem Omayma O OO Fouad Nermeen A NA Ahmed Naglaa A NA Hussein Hoda A HA Ibrahem Enas G EG Mohamed Abdelrahmaan A AA Ahmed Othman M OM Ali Doaa Y DY

Archives of medical science : AMS 20210319 6

<h4>Introduction</h4>The current study was designed to analyze whether polymorphisms of miR-146a and miR-155 are related to Behçet's disease (BD) in the Egyptian population.<h4>Material and methods</h4>A total of 96 unrelated BD patients and 100 healthy subjects were genotyped for miR-146a (rs2910164) and miR-155 (rs767649) using real-time polymerase chain reaction.<h4>Results</h4>The results showed significant elevation in the frequency of rs2910164 GG and CC genotypes in BD patients compared w ...[more]

PMID: 36457982

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Dataset Information

MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet's disease.

Introduction

Material and methods

Results

Conclusions

Publications

MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet's disease.

Similar Datasets

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