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Decarboxylative ring-opening of 2-oxazolidinones: a facile and modular synthesis of β-chalcogen amines.

ABSTRACT: We report herein the synthesis of primary and secondary β-chalcogen amines through the regioselective ring-opening reaction of non-activated 2-oxazolidinones promoted by in situ generated chalcogenolate anions. The developed one-step protocol enabled the preparation of β-selenoamines, β-telluroamines and β-thioamines with appreciable structural diversity and in yields of up to 95%.

SUBMITTER: Galetto FZ

PROVIDER: S-EPMC9710311 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Decarboxylative ring-opening of 2-oxazolidinones: a facile and modular synthesis of β-chalcogen amines.

Galetto Fábio Z FZ da Silva Cleiton C Beche Ricardo I M RIM Balaguez Renata A RA Franco Marcelo S MS de Assis Francisco F FF Frizon Tiago E A TEA Su Xiao X

RSC advances 20221130 53

We report herein the synthesis of primary and secondary β-chalcogen amines through the regioselective ring-opening reaction of non-activated 2-oxazolidinones promoted by <i>in situ</i> generated chalcogenolate anions. The developed one-step protocol enabled the preparation of β-selenoamines, β-telluroamines and β-thioamines with appreciable structural diversity and in yields of up to 95%. ...[more]

PMID: 36545628

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