Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials.

ABSTRACT:

Introduction

Neurodevelopmental disorders are a group of disorders thought to be associated with the functioning of the brain and the nervous system. Children with neurodevelopmental disorders often have sleep-related comorbidities that may negatively affect quality of life for both the children and their families. Melatonin is one of the most used interventions in children with neurodevelopmental disorders and sleep disorders. Previous reviews have investigated the effects of melatonin for sleep disorders in children with neurodevelopmental disorders, but these had important limitations, such as inadequate analysis of adverse effects, small sample sizes and short follow-up.

Methods and analysis

This is a protocol for a systematic review with meta-analysis and Trial Sequenti

SUBMITTER: Jorgensen CK 

PROVIDER: S-EPMC9710329 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature