Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review.

ABSTRACT:

Background

To study whether there is genetic overlap underlying the risk for schizophrenia spectrum disorders (SSDs) and low intelligence quotient (IQ), we reviewed and summarized the evidence on genetic variants associated with both traits.

Methods

We performed this review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and preregistered it in PROSPERO. We searched the Medline databases via PubMed, PsycInfo, Web of Science and Scopus. We included studies in adults with a diagnosis of SSD that explored genetic variants (single nucleotide polymorphisms [SNPs], copy number variants [CNVs], genomic insertions or genomic deletions), estimated IQ and studied the relationship between genetic variability and both traits (SSD and IQ

SUBMITTER: Murillo-Garcia N 

PROVIDER: S-EPMC9710545 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature