β-Lactam-Resistant Streptococcus pneumoniae Dynamics Following Treatment: A Dose-Response Meta-analysis.

ABSTRACT:

Background

Patient exposure to antibiotics promotes the emergence of drug-resistant pathogens. The aim of this study was to identify whether the temporal dynamics of resistance emergence at the individual-patient level were predictable for specific pathogen-drug classes.

Methods

Following a systematic review, a novel robust error meta-regression method for dose-response meta-analysis was used to estimate the odds ratio (OR) for carrying resistant bacteria during and following treatment compared to baseline. Probability density functions fitted to the resulting dose-response curves were then used to optimize the period during and/or after treatment when resistant pathogens were most likely to be identified.

Results

Studies of Streptococcus pneumoniae treatment with β-l

SUBMITTER: Griskaitis M 

PROVIDER: S-EPMC9710638 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature