Dataset Information

Portuguese version of the CDR plus NACC FTLD: Validation studies.

ABSTRACT:

Introduction

The CDR Dementia Staging Instrument PLUS National Alzheimer's Coordinating Center (CDR plus NACC FTLD) was developed by adding to the standard CDR two extra domains focused on the main features of frontotemporal lobar degeneration (FTLD): language and behavior/personality. We intended to perform the validation studies for the European-Portuguese population.

Methods

A total of 105 participants matched for age, education, and disease staging (35 bvFTD, 35 AD, and 35 controls) were included. A translated-version of the CDR and the two added domains was administered by a neuropsychologist who was blinded to the diagnosis.

Results

The bvFTD group had higher baseline CDR plus NACC FTLD scores compared to the AD and controls. Only the sum-of-boxes (SB) score, the behavior/personality, and language domains were able to distinguish between clinical groups. Logistic regression analyses showed that adding the behavior/personality domain with or without language significantly enhanced the discriminating ability.

Discussion

Results show that the CDR plus NACC FTLD is a reliable tool in the diagnostic process of bvFTD patients and has an added value in distinguishing them from patients with AD.

SUBMITTER: Lima M

PROVIDER: S-EPMC9710719 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Portuguese version of the CDR plus NACC FTLD: Validation studies.

Lima Marisa M Tábuas-Pereira Miguel M Durães João J Faustino Pedro P Simões Mário R MR Kukull Walter W Knopman David S DS Santana Isabel I

Alzheimer's & dementia (Amsterdam, Netherlands) 20221130 1

<h4>Introduction</h4>The CDR Dementia Staging Instrument PLUS National Alzheimer's Coordinating Center (CDR plus NACC FTLD) was developed by adding to the standard CDR two extra domains focused on the main features of frontotemporal lobar degeneration (FTLD): language and behavior/personality. We intended to perform the validation studies for the European-Portuguese population.<h4>Methods</h4>A total of 105 participants matched for age, education, and disease staging (35 bvFTD, 35 AD, and 35 con ...[more]

PMID: 36466956

Similar Datasets

Project description:Psychosocial risks are now widely recognised as one of the biggest challenges for occupational safety and health (OSH) and a major public health concern. The aim of this paper is to investigate the Portuguese long version of the Copenhagen Psychosocial Questionnaire II (COPSOQ II), in order to analyse the psychometric properties of the instrument and to validate it.The Portuguese COPSOQ II was issued to a total of 745 Portuguese employees from both private and public organisations across several economic sectors at a baseline and then 2 weeks later. Methodological quality appraisal was based on COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) recommendations. An analysis of the psychometric properties of the long version of COPSOQ II (internal consistency, intraclass correlation coefficient, floor and ceiling effects, response rate, missing values, mean and standard deviation, exploratory factor analysis) was performed to determine the validity and reliability of the instrument.The COPSOQ II had a response rate of 60.6% (test) and a follow-up response rate of 59.5% (retest). In general, a Cronbach's alpha of the COPSOQ scales (test and retest) was above the conventional threshold of 0.70. The test-retest reliability estimated by the intraclass correlation coefficient (ICC) showed a higher reliability for most of the scales, above the conventional 0.7, except for eight scales. The proportion of the missing values was less than 1.3%, except for two scales. The average scores and standard deviations showed similar results to the original Danish study, except for eight scales. All of the scales had low floor and ceiling effects, with one exception. Overall, the exploratory factor analysis presented good results in 27 scales assuming a reflective measurement model. The hypothesized factor structure under a reflective model was not supported in 14 scales and for some but not all of these scales the explanation may be a formative measurement model.The Portuguese long version of COPSOQ II is a reliable and valid instrument for assessing psychosocial risks in the workplace. Although the results are good for most of the scales, there are those that should be evaluated in greater depth in future studies. This instrument may contribute to the promotion of a healthy working environment and workforce, providing clear benefits for companies and employees.

Project description:BackgroundThe Rating-of-Fatigue (ROF) scale is a validated tool to measure changes in perceived fatigue in sports and everyday contexts; thus, this study aimed to translate and validate the Portuguese version of the ROF scale. For this, the study was composed of three phases. Phase 1 involved a comprehensive translation of the ROF scale into Portuguese, followed by a back-translation and a consolidation process to obtain the final version of the ROF scale in Portuguese. In phase 2, the face validity of the scale was assessed. Seventy-three native Portuguese speakers responded to a series of Likert scale items designed to evaluate the purpose of the scale and assess whether it accurately measured the intended construct. In the final phase, the convergent and divergent validity of the scale was assessed during an incremental cycling test to exhaustion, followed by 10 min of passive recovery and a subsequent repetition of the initial 5 min of the test. The study was conducted between October 2023 and June 2024 in Portugal.ResultsThe results from phase 1 indicated a high level of comparability and interpretability between the original and back-translated versions, with only minor adjustments made to finalize the Portuguese version of the ROF scale. In phase 2, a high level of face validity was observed. The median score for the item "measures fatigue" was (median [IQR]) was 3.0 [3.0, 4.0] out of 4. After participants were provided with the scale instructions, the face validity score improved significantly (4.0 [3.0, 4.0]; p = 0.001). In phase 3, during the incremental test, very large correlations were observed between ROF, and key physiological and performance indicators, including rating of perceived exertion (RPE), heart rate, oxygen consumption, and power output. Discriminant validity between ROF and RPE was found during the recovery.ConclusionsThe present study indicates that the Portuguese version of the ROF maintains the properties of the original version and can be used effectively in the Portuguese language.

Project description:BackgroundTRACK (Test for Respiratory and Asthma Control in Kids) questionnaire is an instrument developed and validated in English to evaluate the control of respiratory symptoms in children under 5 years of age.ObjectiveTo validate the Portuguese version of the TRACK questionnaire.MethodsThe validation was done in an observational, prospective and multicenter evaluation (six centers in Brazil) in children with recurrent respiratory symptoms. Children were classified according to symptoms, GINA criteria and medical evaluation. Parents and doctors rated child respiratory symptom control in the last month (VAS). Approval from the Institutional Review Board was obtained in each centre, and written informed consent was obtained from parents.ResultsData from 299 children were obtained at baseline, and 195 at follow-up. The median score of the TRACK questionnaire was 65 and Cronbach's α was 0.70. TRACK scores showed significant correlation with the medical and family opinions about symptom control (r: 0.74 and r: 0.61). TRACK scores were significantly lower in children who had used systemic steroids (median [IQR]: 45 [30-65] vs 75 [55-80]; p < 0.001) and had an emergency visit in the last month (45 [35-60] vs 70 [55-80]; p < 0.001). TRACK scores were also significantly different when children were separated by the medical opinion, GINA criteria and symptoms. Comparison of different respiratory symptom control cut-off points showed that the cut-off of 80 points had the highest area under ROC curve (0.800).ConclusionWe have demonstrated that the Portuguese version of the TRACK questionnaire has satisfactory reliability (internal consistency), adequate criterion validity (compared against GINA levels of control) and constructive validity (compared against respiratory symptoms and medical opinion), showing that it can be a useful tool to discriminate among children with different levels of respiratory symptom control.Trial registrationClinicalTrials.gov: NCT03290222.

Dataset Information

Portuguese version of the CDR plus NACC FTLD: Validation studies.

Introduction

Methods

Results

Discussion

Publications

Portuguese version of the CDR plus NACC FTLD: Validation studies.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets