A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.

ABSTRACT:

Objective

Preference for dietary fat vs. carbohydrate varies markedly across free-living individuals. It is recognized that food choice is under genetic and physiological regulation, and that the central melanocortin system is involved. However, how genetic and dietary factors interact to regulate relative macronutrient intake is not well understood.

Methods

We investigated how the choice for food rich in carbohydrate vs. fat is influenced by dietary cholesterol availability and agouti-related protein (AGRP), the orexigenic component of the central melanocortin system. We assessed how macronutrient intake and different metabolic parameters correlate with plasma AGRP in a cohort of obese humans. We also examined how both dietary cholesterol levels and inhibiting de novo chole

SUBMITTER: Nelson NG 

PROVIDER: S-EPMC9710720 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature