Lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans

ABSTRACT: For the nervous system to develop properly, neurons must connect in a precise way to form functional networks. This requires that outgrowing neuronal processes (axons) navigate to their target areas, where they establish proper synaptic connections. The molecular basis of this navigation process is not firmly understood. A candidate family containing putative receptors acting in various aspects of neuronal development including axon navigation are transmembrane proteins of the extracellular Leucine-Rich Repeat family (eLRRs). We systematically tested members of this family in C. elegans for a role in axon navigation in the ventral nerve cord (VNC). We found that lron-11 mutants showed VNC navigation defects in several classes of neurons, including a pioneer neuron and various classes of in

SUBMITTER: Kokan N 

PROVIDER: S-EPMC9710760 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature